SARMs: A Completed Guide To Build More Muscles With SARMs
Performance-enhancing drugs have stirred quiet a number of argument and controversy ranging from complements to criticism. Performance-enhancing drugs are interchanged with steroids but in the real sense, both are two different compounds. The evolution of a new class of performance-enhancing drug, a compound collectively called selective androgen receptor modulators (SARMs) evolved about a decade ago.
SARMs works like steroids as it helps build muscles and burns out fat. SARMs does this without shrinking the balls, destroying the functionality of liver, or abnormal hair growth. SARMs architecture is designed to act on target hormones which considerably buildup of muscles and reduces fat.
Most research on SARMs were conducted on rats, as researchers are yet to study SARMs in human over a long-term exposure period to validate safety. If you have thoughtfully considered upgrading physical performance, SARMs is an option to consider.
SARMs on the cutting edge over steroids
Steroids lend aid to build muscle by augmenting the increase of testosterone, which consequently increase protein synthesis in cells, while it builds muscles and burns fat. Taking steroids have a wide range of effect; it affects the liver, prostate, heart, sex organs (causing the ball shrink in men and enlargement of clitoris in women). It also affects secondary sexual characteristics like deepening of voice, body hair growth, man boobs, acne to mention but a few. The aforementioned are the androgenic side effect of steroids.
Growing concern about steriods is that they have a configuration of an anabolic-to-androgenic ratio of 1:1. Implying that they help to build muscles and also extact effects on sex organs like shrinking balls or enlarge clitoris. The effect of this can be controlled if one can optimize hormone level and this must be under a careful supervision of doctor.
SARMs improve on the lapse of steriods due to its biological configuration and this makes them more preferable to steroids. SARMs innovates boasting anabolic-to-androgenic ratios starting from 3:1 and can be varied as high as 90:1. The implication of this is that the user will experience growth in muscle and fat reduction with no phenotypical changes like the appearance of boobs in men and appearance of beards in lady. SARMs is administered orally unlike steroids which is injected. Good news, today, we have more SARMs undergoing either clinical trials or animal trials.
MK-2866 also called Ostarine; It is among the few studied SARMs which has featured and published multiple human trials. Ostarine significantly shows no side effects and its very effective at building muscles. Modest doses of Ostarine taken by elderly men and women for an exposure period of 12 weeks grew 3 pounds of muscles and lost a pound of fat, with no changes in diet or exercise.
Cancer patients exposed to treatment of Ostarine within the same time frame as in the case of the elder men and women had almost identical result, with no negative consequence for each studies. A diligent workout routine for a month should give you a pound of muscle but the studies conducted has shown that the people who gained a pound of muscle weren’t involved in exercise. A combination of Ostarine and exercise can yield remarkable result.
Side effects of MK-2866
The clinical trials of Ostarine has no evidence of side effects but consumers report short-term testosterone suppression which occurs when they take high doses of ostarine for a period of 8-12 weeks. The level of testosterone regains normalcy within a few weeks of no exposure.
Dosage of MK-2866
Medically, there has not been a recommended dose intake for SARMs most probably because they are still new in the line of research. In the case of ostarine, report from online communities has it that an intake of 15-20mg daily of Ostarine for 4 weeks is moderate. Some cautiously, suggests to take at least 4weeks off to restore balance to biological system before one commence another cycle of exposure. Also, combination of Ostarine with the other SARMs, appears to pair best with regular exercise like lifting.
LGD-4033, also known as Anabolicum, it is also belonging to the few group of SARMs that has been studied. Record has it that Anabolicum has gone through several clinical trials showing praise-worthy results. Some of the result include.
- Healthy men exposed to Anabolicum for a period 21 days saw a significant increase in lean body mass. A notable side effect was a short-term in which the user experience testosterone suppression. One milligram daily was enough to cause significant muscle growth. The higher the dose, the more muscle users put on.
- Result from another trial shows that participants who were exposed to about 22mg/day do not have any evidence of side effect or safety challenges.
- In preclinical trial, in rats, its shown that Anabolicum increases bone density, muscle mass, and sex drive, without damaging prostate or liver tissue.
Side effects of LGD-4033
LGD-4033 might suppress natural testosterone production in the course of taking the dosage. This effect appears to be short-lived. T suppression is dependent on dose concentration in participants, but none of the participants experience a drop in testosterone range and levels returned to normal within 3 weeks after they stopped taking LGD-4033.
How to dose LGD-4033
Consumers who took between 2-5 mg of LGD-4033 daily for a period of 4 weeks gave good credit. Other users, proclaim that at higher the dose, the more muscle gain and the more testosterone dips. It recommended by the consumers to stay off the usage of LGD-4033 for a period of a month before you commence another cycle of exposure.
GW501516 also known as Cardarine is yet to have a publish human studies. However, in animal trial, rodents, it shows promise as an exercise mimetic. It activates many of the genes you would activate if one runs or lifts weight. Researchers had mice take GW501516 with consistent exercise, the results were mind blowing.
In mice, GW501516 combined with 4 weeks of regular running increased running time by 68% and running distance by 70%, and doubled overall muscular endurance.
- In rodents, GW501516 plus exercise increased mitochondrial growth in muscle by ~50%, allowing muscles to generate more power without fatigue.
- In mice it also decreased fat while preserving muscle.
GW501516 could be a powerful way to improve performance and shed fat while maintaining muscle. We are anticipating that human studies with GW501516 will come out soon.
Side effects of GW501516
Studies are yet to provide prove that GW501516 is carcinogenic. Although there are claims that W501516 caused cancer in lab rats. The studies found no evidence that GW501516 causes cancer at a dose appropriate for human. Other studies report no side effects in rats while online SARMs community report none either, including no testosterone suppression but advice to use with caution.
How to dose GW501516
Although there are yet to be a recommended dosage for GW501516. Reports from users has it that it works best if you split it into two daily doses. 5 mg, morning and afternoon, a total of 10 mg daily for 4 weeks while you stay off for another 4 weeks before you repeat the cycle. It could also be used alongside with LGD-4033 and MK-2866.
S4 (andarine) was the oldest SARM. Users report modest strength and muscle gain, as well as modest fat loss. S4 seems to work best if you use it alongside other SARMs. It pairs well with MK-2866 and LGD-4033. Both suppress testosterone at higher doses.
Side effects of S4
S4 has been associated with visual abnormality but officially they are no studies to affirm this report. Users report altered color perception and nighttime blindness after taking S4 for a couple weeks, this could be because one of S4’s metabolites binds to receptors in the eyes.
How to dose S4?
50 mg daily, as with all the other SARMs on this list, take it daily for 4 weeks, and then wait at least 4 weeks before starting another cycle.
SR9009 also known as Stenabolic, is highly esteemed as “exercise in a pill,” seems like the perfect supplement. In mice, it increases endurance and fat burning, decreases inflammation, and stimulates the growth of new mitochondria in muscle cells. Obese rats injected with SR9009 lost 60% more, without changing diet or exercise.
The possibility that SR9009 works in humans makes it the choicest of the SARMs. The animal trials conducted shows that the rats used for the trials were injected. Taking SR9009 orally is not effective as it has about 2% oral bio-availability, and the system clears that 2% almost immediately.
Nutrobal (MK-677) is a chemical that has the characteristics of human growth hormone (HGH). It is an orally active growth hormone secretagogue. A secretagogue causes substances to be secreted. MK677 has the ability because of its ability to mimic the GH stimulating action a hormone called “ghrelin.” Ghrelin is categorized as a peptide, commonly referred to as “the hunger hormone,” which explains the drastic rise in appetite with 677 use. Ghrelin plays a large role in regulating the distribution as well as rate of energy use. It is imperative to understand all of these concepts to decipher the many capabilities that 677 has. mk677 can not only increase plasma levels of many types of hormones, but also provide sustainable increases. These are long term and not just “for the time being” types of increases. Studies show that Nutrobal can increase muscle mass and bone mineral density as well as altering the metabolism of body fat, possibly becoming a treatment for obesity.
BENEFITS OF MK-677:
Nutrobal (MK-677) studies have been conducted since the late 90’s. There is a wide array of benefits that have been found with use. The main benefit that consistently shows in study is the increase in growth hormone and IGF-levels provided with use. These have shown to be significant increases in regards to both. Below is a list of other significant benefits found through studies and implementation on humans:
- Increases in fat free mass
- Enhanced sleep quality
- A treatment for obesity and fat loss
- Lowering of bad cholesterol (LDL)
- Significant improvements in nitrogen balance
- Reversal of diet-induced nitrogen wasting
- Treatment of catabolic conditions
- Increase in basil metabolic rate
- Oral administration (no injections required)
- Overall sense of well-being
It is evident by the list of benefits that MK677 is highly desirable. These benefits, in conjunction with the very small chance of side effects show MK677 to be a breakthrough.
As stated above, MK677 carries little to no side effects however it is always important to understand the possibilities that could occur with use.
The main “side effect” associated with MK677 is the increase in appetite, which may be welcome by many research subjects. Studies show this to subside after 4-8 weeks, variant from person to person. The other side effects that showed, that were very infrequent and uncommon were mild lower extremity edema and muscle pain. Secretagogues generally carry the worry of prolactin increase, however studies with MK677 did not show any increase in prolactin levels. Cortisol levels were not increased in studies either. These traits make Nutrobal stand out amongst other chemicals that attempt to work in the same manner but carry these unwanted side effects.
Studies conducted had dosing between 5-25 mg per day, with 25 mg being the most common and effective dose. MK677 has a 24 hour half life and showed to be best tolerated when fed to rats each morning on an empty stomach. MK677 has extreme benefits in regards to helping with a deeper sleep however it can interfere with sleep patterns if taken too late at night or too close to bed time. MK677 can be used continuously for 1-2 years with no concern of desensitizing.
RAD-140 is designed to make hormonal receptors in the tissues act as though they are getting a strong dose of testosterone. This gives the same effect as if running a cycle of anabolics and/or prohormones without the negative side effects that correlate with use.
Along with the effects of testosterone discussed above, Testolone (RAD-140) also carries other significant benefits. Enhanced speed, stamina and endurance when doing high intensity is a key benefit shown in research tests with RAD implementation. Another huge benefit shown with RAD research is a rapid buildup of muscular tissues. Studies have also shown that RAD contains a greater anabolic effect than testosterone when used.
Studies are still being conducted to ensure the proper doses are recommended for testing to maximize the research benefits. Studies to date have implemented a method of 0.3, 3 and 30 milligrams of RAD per day based on body weight of the research subject; however, many have come to the conclusion that 20-30 milligrams per day is the proper protocol for the most benefit in the safest manner of research dosing.
There have not been any side effects found to date. This is also a breakthrough considering that regular testosterone causes drastic suppression where RAD has not shown these kinds of issue, nor has it shown any estrogen conversion or any typical testosterone, anabolic and androgenic side effects.
Based on current findings and testing, RAD is showing to be a significant breakthrough in the medical field. While very new and still being tested, results thus far have been nothing but encouraging and as time progresses, RAD will likely become widely known as a replaced for testosterone replacement therapy or a safer alternative. Time will tell but research indicates a bright future
RESEARCH******RESEARCH USE ONLY***
*This information here is intended for educational and informational purposes only. THIS PRODUCT IS INTENDED FOR RESEARCH USE ONLY. This allows you to do lab research with the product, it is strictly used for in vitro testing and laboratory experiments.